COMBINING HEPATIC PERCUTANEOUS PERFUSION WITH IPILIMUMAB PLUS NIVOLUMAB IN ADVANCED UVEAL MELANOMA (CHOPIN): STUDY PROTOCOL FOR A PHASE IB/RANDOMIZED PHASE II TRIAL

Abstract Background While immune checkpoint inhibition (ICI) has revolutionized the treatment of metastatic cutaneous melanoma, no standard treatments are available for patients with metastatic uveal melanoma (UM).Several locoregional therapies are effective in the treatment of liver metastases, such as percutaneous hepatic perfusion with melphalan

Lignocellulosic (LC) biomass is abundantly available as a low-cost resource on the Earth.LC conversion into energy carriers is the most accepted alternative energy production policy because it is non-competitor to food or feed.LC ethanol has brought cellulases to the forefront which was MASS STRAWBERRY otherwise lost in oblivion during last decades

Conditions in which abnormal or excessive immune responses exist, such as Vest Top autoimmune diseases (ADs), graft-versus-host disease, transplant rejection, and hypersensitivity reactions, are serious hazards to human health and well-being.The traditional immunosuppressive drugs used to treat these conditions can lead to decreased immune function

The aim of this study was to investigate the effects of thermally compressed veneer laminating on some of the physical and mechanical properties of particleboard.Oriental beech (Fagus orientalis Lipsky) veneers were compressed under various press conditions.Commercially produced particleboard samples were laminated with such compressed veneer sheet